This advanced pharmaceutical manufacturing facility is the lead plant responsible for initial production runs by the Astellas Group, which specializes in investigational new drugs and recently commercialized products. The building realizes an ideal manufacturing environment through rationalization of the production flow, enhanced efficiency, automation of materials handling facilities, and one-way flow lines for people and goods. The base-isolated building incorporates the latest technical innovations and prioritizes business continuity. The upper structure has few variations and the building employs a structural frame that emphasizes flexibility and extensibility. Mid-level floors utilize story height to enable overhead views of the production line by visitors. Through such features as a high-precision air conditioning system, a backup fire safety system, and the use of renewable energy, the design strives to provide safety, security, a low environmental footprint, and reduced volume impact on the surrounding neighborhood.